Principal Investigator, DBME Research Group

PhD in Drug Discovery (King’s College London)

Commonwealth Scholar 🌐

mahbub.hasan@cu.ac.bd

Dr. Md. Mahbub Hasan, a Commonwealth Scholar from Mymensingh near the Brahmaputra River, completed his education at Shahjalal University of Science and Technology, SUST, Sylhet-3114. He then joined Incepta Pharmaceuticals Ltd in 2013 as an R&D Officer, contributing significantly to Biosimilar production, especially Insulin Glargine, and excelling in mass spectrometry and computational biology. During his industrial tenure, Dr. Hasan received extensive training in liquid chromatography, biotherapeutics production, and mass spectrometry from global leaders like AB Sciex and GE Healthcare. In 2015, he transitioned to academia, joining the University of Chittagong’s Department of Genetic Engineering and Biotechnology as a Faculty Member. Additionally, Dr. Hasan pursued his PhD at King’s College London, focusing on Drug Discovery in cancer treatment. His research led to the development of cutting-edge anticancer payloads for Antibody-Drug Conjugates (ADCs), with hands-on experience in Synthetic Chemistry, Cell Culture, and Cancer Biology. These compounds are now in the commercialization pipeline for further advancement.

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Professional membership

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Publications

2024

1. Genetic determinants of SARS-CoV-2 and the clinical outcome of COVID-19 in Southern Bangladesh Md. Mahbub Hasan, Chayan Kumar Saha, H. M. Hamidullah Mehedi, Kallyan Chakma, Asma Salauddin, Md. Shakhawat Hossain, Farjana Sharmen, S. M. Rafiqul Islam, Afroza Akter Tanni, Farhana Yasmin, Al-Shahriar Akash, Mohammad Enayet Hossain, Mojnu Miah, Sanjoy Kanti Biswas, Nahid Sultana, Adnan Mannan Immun Inflamm Dis. 2024; 12:e1171

2023

1. Knowledge and attitudes of thalassaemia among high-risk indigenous university students in Bangladesh: A pilot study Md. Mahbub Hasan, Khaza Md. Kapil Uddin, Syed Mohammad Lokman, Kallyan Chakma, Aung Chaing-U Pulu, Adnan Mannan, Enayetur Raheem, Shahed Ahmad Chowdhury, Mohammad Sorowar Hossain PLOS ONE 18(7): e0287630
2. Risk perception of sun exposure and knowledge of vitamin D among the healthcare providers in a high-risk country: a cross-sectional study Mahbubul H. Siddiqee, Badhan Bhattacharjee, Mahbub Hasan, Mohammad Shojon, Mehedi Hassan, Rashawan Raziur Rouf, Umme Raihan Siddiqi, Fazlay Rabbi & Umme Ruman Siddiqi BMC Medical Education volume 23, Article number: 46 (2023)

2022

1. Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage Asha Mary Joseph , Kazi Nahar , Saheli Daw , Md. Mahbub Hasan , Rebecca Lo , Tung Le , Khondaker Miraz Rahman and Anjana Badrinarayanan. RSC Medicinal Chemistry; 2022,13, 1621-1633
2. Association between TCF7L2 polymorphism and type 2 diabetes mellitus susceptibility: a case–control study among the Bangladeshi population A. Salauddin, K. Chakma, M.M Hasan, F. Akter, N.A. Chowdhury, S.R. Chowdhury, A Mannan Molecular Biology Reports; Springer Nature Switzerland AG.; page: 2022; October 2022
3. Investigating Antimicrobial Resistance and ESBL Producing Gene in Klebsiella Isolates among Neonates and Adolescents in Southern Bangladesh. Afroza Akter Tanni, Nahid Sultana, Wazir Ahmed, Md. Mahbub Hasan, Md Hossain, Sajjad Hossain Noyon, Adnan Mannan Canadian Journal of Infectious Diseases and Medical Microbiology; Hindawi; page: 2022:7071009; August 2022
4. The relationship between medical comorbidities and health-related quality of life among adults with type 2 diabetes: The experience of different hospitals in southern Bangladesh. Adnan Mannan, Farhana Akter, Naim Uddin Hasan A. Chy, Nazmul Alam, Md. Mashud Rana, Nowshad Asgar Chowdhury, Md. Mahbub Hasan PLoS ONE; PLOS; page: 17(5): e0267713; May 2022

2021

1. The parental perspective of thalassaemia in Bangladesh: lack of knowledge, regret, and barriers Mohammad Sorowar Hossain, Md. Mahbub Hasan, Mary Petrou, Paul Telfer & Abdullah Al Mosabbir
   Orphanet Journal of Rare Diseases; BioMed Central Ltd. part of Springer Nature.; page: 16: 315 (2021); July 2021
   2020 Journal Impact Factor 4.123
2. Major Insights in Dynamics of Host Response to SARS-CoV-2: Impacts and Challenges Al Hakim, Md. Mahbub Hasan, Mahmudul Hasan, Syed Mohammad Lokman, Kazi Faizul Azim, Topu Raihan, Parveen Afroz Chowdhury and Abul Kalam Azad
   Frontiers in Microbiology; Frontiers Media S.A.; July 2021
   2020 Journal IF 5.64
3. Insights into the first seven-months of COVID-19 pandemic in Bangladesh: lessons learned from a high-risk country MHB Siam, Md. Mahbub Hasan, SM Tashrif, MHR Khan, E Raheem, MS Hossain
   Heliyon; Celll Press; page: 7(1):e07385; June 2021
   
4. Global and Local Mutations in Bangladeshi SARS-CoV-2 Genomes Md. Mahbub Hasan, Rasel Das, Md. Rasheduzzaman, Md. Hamed Hussain, Nazmul Hasan Muzahid, Asma Salauddin, Meheadi Hasan Rumi, S.M. Mahbubur Rashid, Zonaed Siddiki AMAM, Adnan Mannan
   Virus Research (IF 3.303); Elsevier B.V.; page: 198390; March 2021
    
5. Genome-wide Characterization Deciphers Distinct Properties of Aquaporins in Six Phytophthora species Abul Kalam Azad*, Jahed Ahmed, Al Hakim, Md. Mahbub Hasan, Md. Asraful Alum, Mahmudul Hasan, Topu Raihan, Takahiro Ishikawa and Yoshihiro Sawa
   Current Bioinformatics; Bentham Science Publisher; page: (2021) 16: 1; February 2021
   Impact Factor (2020): 3.543
6. Therapeutic Intervention of COVID-19 by Natural Products: A Population-Specific Survey Directed ApproachChristian R. Gomez, Ingrid Espinoza, Fazlay S. Faruke, Md. Mahbub Hasan, Khondaker Miraz Rahman, Larry A. Walker, Ilias Muhammad
   Molecules; MDPI (Basel, Switzerland); February 2021
   Impact Factor 4.411
7. Factors associated with low adherence to medication among patients with type 2 diabetes at different healthcare facilities in southern BangladeshAdnan Mannan , Md. Mahbub Hasan, Farhana Akter , Md. Mashud Rana , Nowshad Asgar Chowdhury , Lal B. Rawal & Tuhin Biswas
   Global Health Action; Informa UK Limited; page: 14:1, 1872895; January 2021
   Impact Factor: 2.640 SJR: Q1 (Health Policy)

2020

1. Clinical characteristics and short term outcomes after recovery from COVID-19 in patients with and without diabetes in BangladeshFarhana Akter, Adnan Mannan, H.M. Hamidullah Mehedi, Abdur Rob, Shakeel Ahmed, Asma Salauddin, Md Shakhawat Hossain, Md. Mahbub Hasan
   Diabetes & Metabolic Syndrome: Clinical Research & Reviews; Elsevier B.V.; October 2020
2. Current Trends and Future Approaches in Small-Molecule Therapeutics for COVID-19 Mark Laws, Yasmin M Surani, Md Mahbub Hasan et al.
   Current Medicinal Chemistry; July 2020
   Impact Factor: 4.530
3. Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: A computational biology approachSyed Mohammad Lokman, Md. Rasheduzzaman, Asma Salauddin, Rocktim Barua, Afsana Yeasmin Tanzina, Meheadi Hasan Rumi, Md. Imran Hossain, A.M.A.M. Zonaed Siddiki, Adnan Mannan, Md. Mahbub Hasan
   Infection, Genetics and Evolution; Elsevier B.V.; June 2020
   Impact Factor: 3.342
4. Lack of knowledge and misperceptions about thalassaemia among college students in Bangladesh: a cross-sectional baseline studyM.S. Hossain, Md. Mahbub Hasan, E. Raheem, M.S. Islam, A.A. Mosabbir, M. Petrou, P. Telfer, M.H. Siddiqee
   Orphanet Journal of Rare Diseases; BioMed Central Ltd; page: In press; February 2020
   Impact factor: 4.123

2019

1. Manifestations of atypical symptoms of Chikungunya during the Dhaka outbreak (2017) in BangladeshI. Deeba, MM Hasan, A.A. Mosabbir, M.H.B. Siam, E. Raheem and M.S. Hossain
   American Journal of Tropical Medicine and Hygiene (2019), 100(6); The American Society of Tropical Medicine and Hygiene; page: 1545-1548; April 2019
   Impact factor 2.345

2018

1. Chikungunya outbreak (2017) in Bangladesh: Clinical profile, economic impact and quality of life during the acute phase of the diseaseMS Hossain, MM Hasan, MS Islam, S Islam, M Mozaffor, MAS Khan, …
   PLoS neglected tropical diseases 12 (6), e0006561, 2018; 2018
   Impact factor 4.367
2. Prediction of arsenic and antimony transporter major intrinsic proteins from the genomes of crop plantsAK Azad, J Ahmed, MA Alum, MM Hasan, T Ishikawa, Y Sawa
   International Journal of Biological Macromolecules 107, 2630-2642, 2018; 2018
   Impact factor 3.909

2017

1. Optimization of some fermentation conditions for the production of extracellular amylases by using Chryseobacterium and Bacillus isolates from organic kitchen wastes MM Hasan, LW Marzan, A Hosna, A Hakim, AK Azad
   Journal of Genetic Engineering and Biotechnology 15 (1), 59-68, 2017; 2017
   PMID:30647642
2. In silico identification and characterization of common epitope-based peptide vaccine for Nipah and Hendra viruses CK Saha, MM Hasan, MS Hossain, MA Jahan, AK Azad
   Asian Pacifc Journal of Tropical Medicine 10 (6), 529-538, 2017; 2017
   Impact factor 1.634
3. Characterization of furnace oil bioremediation potential of hydrocarbonoclastic bacteria isolated from petroleum contaminated sites of the Sundarbans, Bangladesh LW Marzan, T Sultana, MM Hasan, SA Mina, MR Islam, …
   Journal of Genetic Engineering and Biotechnology 15 (1), 103-113, 2017; 2017
   PMID:30647647
4. Pattern of hematological malignancies in adolescents and young adults in Bangladesh MM Hasan, E Raheem, TA Sultana, MS Hossain
   Cancer Epidemiology 51, 109-112, 2017; 2017
   Impact factor 2.888

2016

1. Genome-Wide Characterization of Major Intrinsic Proteins in Four Grass Plants and Their Non-Aqua Transport Selectivity Profiles with Comparative Perspective AK Azad, J Ahmed, MA Alum, MM Hasan, T Ishikawa, Y Sawa, …
   PLoS ONE 11 (6), e0157735, 2016; 2016
   Impact factor 2.766

2014

1. Production of microbial lipids from rice straw hydrolysates by lipomyces starkeyi for biodiesel synthesisA Azad, A Yousuf, A Ferdoush, MM Hasan, MR Karim
   J Microb Biochem Technol S 8 (2), 2014; 2014

2013

1. Fermentation of municipal solid wastes by bacterial isolates for production of raw protein degrading proteasesAK Azad, A Nahar, MM Hasan, K Islam, MF Azim, MS Hossain, …
   Asian Journal of Microbiology, Biotechnology & Environmental Sciences 15 (2 …, 2013; 2013
2. Production and Partial Characterization of Cellulase from Pseudomonas Isolates Obtained from Cow Dung and Municipal Solid WastesMMH Sohag, MM Hasan, J Ahmed, SNA Daud, MK Alam, MR Amin, …
   Bangladesh Journal of Microbiology 30 (1&2), 11-16, 2013; 2013

2011

1. Molecular cloning and sequence and 3D models analysis of the Sec61α subunit of protein translocation complex from Penicillium ochrochloron AK Azad, MA Jahan, MM Hasan, T Ishikawa, Y Sawa, H Shibata
   BMB Reports 44 (11), 719-24, 2011; 2011
   Impact Factor 3.085

Training and visits

• 2018 Foundation Training on Teaching-Learning and Research Methodology
  Graduate Training Institute, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh
• 2017 Training Workshop on Biosafety Regulatory System and Network Development, Department of Environment, Ministry of Environment and Forests, Government of the People’s Republic of Bangladesh
• 2014 Fast Trak training on “Introduction to Bioprocessing Upstream and Downstream (Tailored Course)” GE Healthcare Life Sciences, India
• 2014 Advances in Human Genetics: Clinical and Research Applications
  Institute of Developing Science and Health Initiatives (ideSHi), Dhaka, Bangladesh
• 2013 Advanced Training on Mass Spectrometry
  AB Sciex, India